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IgE to the Mammalian Oligosaccharide Galactose-{alpha}-1,3-Galactose... » Isaúde
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Nome da revista:   Volume:   Número:
Arteriosclerosis, Thrombosis, and Vascular Biology
2018-06-27 17:45:10

IgE to the Mammalian Oligosaccharide Galactose-{alpha}-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics—Brief ReportHighlights [Clinical and Population Studies]

Assunto: Basic Science Research, Biomarkers, Inflammation, Ultrasound

Descrição: Objective-Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization to the mammalian oligosaccharide galactose---1,3-galactose (--Gal)-the target allergen of delayed anaphylaxis to red meat-is associated with coronary artery disease.Approach and Results-Total IgE and specific IgE to --Gal were assayed on sera from 118 subjects who presented for cardiac catheterization and underwent intravascular ultrasound. IgE to --Gal was detected in 26%, and atheroma burden was higher in sensitized subjects (P=0.02). Because --Gal sensitization relates to an environmental exposure that could be a risk factor for early-onset coronary artery disease (ie, tick bites), we age stratified the cohort. In subjects -65 years of age, the strength of the association with atheroma burden was stronger (P

Editorial: American Heart Association
Seção: Clinical and Population Studies
Número: 7
Volume: 38
Página: 1665 a 1669
Autor: Jeffrey M. Wilson, Anh T. Nguyen, Alexander J. Schuyler, Scott P. Commins, Angela M. Taylor, Thomas A.E. Platts-Mills, Coleen A. McNamara


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