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Comparative Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin... » Isaúde
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Arteriosclerosis, Thrombosis, and Vascular Biology
2018-06-27 17:45:10

Comparative Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition and Statins on Postprandial Triglyceride-Rich Lipoprotein MetabolismHighlights [Clinical and Population Studies]

Assunto: Clinical Studies, Lipids and Cholesterol, Metabolism, Cardiovascular Disease, Risk Factors

Descrição: Objective-Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9) and statins are known to lower plasma LDL (low-density lipoprotein)-cholesterol concentrations. However, the comparative effects of these treatments on the postprandial metabolism of TRLs (triglyceride-rich lipoproteins) remain to be investigated.Approach and Results-We performed a 2-by-2 factorial trial of the effects of 8 weeks of subcutaneous evolocumab (420 mg every 2 weeks) and atorvastatin (80 mg daily) on postprandial TRL metabolism in 80 healthy, normolipidemic men after ingestion of an oral fat load. We evaluated plasma total and incremental area under the curves for triglycerides, apo (apolipoprotein)B-48, and VLDL (very-LDL)-apoB-100. We also examined the kinetics of apoB-48 using intravenous D3-leucine administration, mass spectrometry, and multicompartmental modeling. Atorvastatin and evolocumab independently lowered postprandial VLDL-apoB-100 total area under the curves (P

Editorial: American Heart Association
Seção: Clinical and Population Studies
Número: 7
Volume: 38
Página: 1644 a 1655
Autor: Dick C. Chan, Gerald F. Watts, Ransi Somaratne, Scott M. Wasserman, Rob Scott, P. Hugh R. Barrett

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