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Complexity Analysis of Spontaneous Brain Activity in Alzheimer... » Isaúde
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Alzheimer Disease and Associated Disorders
2010-04-01 00:00:00

Complexity Analysis of Spontaneous Brain Activity in Alzheimer Disease and Mild Cognitive Impairment: An MEG Study

Descrição: Nonlinear analyses have shown that Alzheimer disease (AD) patients' brain activity is characterized by a reduced complexity and connectivity. The aim of this study is to define complexity patterns of mild cognitive impairment (MCI) patients. Whole-head magnetoencephalography recordings were obtained from 18 diagnosed AD patients, 18 MCI patients, and 18 healthy controls during resting conditions. Lempel-Ziv complexity (LZC) values were calculated. MCI patients exhibited intermediary LZC scores between AD patients and controls. A combination of age and posterior LZC scores allowed ADs-MCIs discrimination with 94.4% sensitivity and specificity, whereas no LZC score allowed MCIs---controls discrimination. AD patients and controls showed a parallel tendency to diminished LZC scores as a function of age, but MCI patients did not exhibit such "normal" tendency. Accordingly, anterior LZC scores allowed MCIs-controls discrimination for subjects below 75 years. MCIs exhibited a qualitatively distinct relationship between aging and complexity reduction, with scores higher than controls in older individuals. This fact might be considered a new example of compensatory mechanism in MCI before fully established dementia. (C) 2010 Lippincott Williams & Wilkins, Inc.

Seção: Original Articles
Volume: 0
Autor: Fernández, Alberto; Hornero, Roberto; Gómez, Carlos; Turrero, Agustín; Gil-Gregorio, Pedro; Matías-Santos, Juan; Ortiz, Tomás


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