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The CERAD Neuropsychologic Battery Total Score and the Progression of... » Isaúde
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Alzheimer Disease and Associated Disorders
2010-04-01 00:00:00

The CERAD Neuropsychologic Battery Total Score and the Progression of Alzheimer Disease

Descrição: Objective: To establish the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychologic battery as a valid measure of cognitive progression in Alzheimer disease (AD) by deriving annualized CERAD Total Change Scores and corresponding confidence intervals in AD and controls from which to define clinically meaningful change. Method: Subjects included 383 normal control (NC) and 655 AD subjects with serial data from the CERAD registry database. Annualized CERAD Total Change Scores were derived and Reliable Change Indexes (RCIs) calculated to establish statistically reliable change values. CERAD Change Scores were compared with annualized change scores from the Mini-Mental State Examination (MMSE), Clinical Dementia Rating Scale (CDR) Sum of Boxes, and Blessed Dementia Rating Scale (BDRS). Results: For the CERAD Total Score, the AD sample showed significantly greater decline than the NC sample over the 4-year interval, with AD subjects declining an average of 22.2 points compared with the NCs' improving an average 2.8 points from baseline to last visit [Group x Time interaction [F(4,1031)=246.08, P

Seção: Original Articles
Volume: 0
Autor: Rossetti, Heidi C.; Munro Cullum, C.; Hynan, Linda S.; Lacritz, Laura H.


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