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MRI Substudy Participation in Alzheimer Disease (AD) Clinical Trials:... » Isaúde
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Alzheimer Disease and Associated Disorders
2009-10-01 03:00:00

MRI Substudy Participation in Alzheimer Disease (AD) Clinical Trials: Baseline Comparability of a Substudy Sample to Entire Study Population

Descrição: Objective: To determine if a self-selected group of participants who enroll in an imaging substudy of Alzheimer disease (AD) clinical trials is representative of the overall study sample. Methods: Baseline data from 2 ongoing AD clinical trials with 402 and 313 randomized participants were analyzed. Magnetic resonance imaging substudy enrollers (166 participants in trial 1 and 161 participants in trial 2) and nonenrollers were compared on baseline demographic, medical and clinical characteristics separately for the 2 trials. Results: In both trials, enrollers were statistically similar to nonenrollers on most demographic and clinical measures. One study sample showed that enrollers had lower cognitive scores at baseline when compared with nonenrollers: lower Mini Mental State Examination scores (20.15+/-3.6 vs. 21.04+/-3.6, P=0.02), and higher Alzheimer's Disease Assessment Scale-cognitive domain scores (24.99+/-8.5 vs. 23.03+/-9.3, P=0.03); however, the difference was not considered clinically important and was not observed in the second trial. Conclusions: The groups of individuals who agreed to participate in the imaging substudies of AD trials were remarkably comparable to the comparison groups at baseline on a wide range of demographic and clinical measures; there seems to be a minimal effect of self-selection bias. The results indicate that it may be reasonable to generalize findings in an imaging substudy to the complete the study population. (C) 2009 Lippincott Williams & Wilkins, Inc.

Seção: Original Articles
Volume: 0
Autor: Raman, Rema; Thomas, Ronald G.; Weiner, Michael W.; Jack, Clifford R.; Ernstrom, Karin; Aisen, Paul S.; Tariot, Pierre N.; Quinn, Joseph F.

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