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Rate of Decline in Alzheimer Disease Measured by a Dementia Severity... » Isaúde
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Alzheimer Disease and Associated Disorders
2009-07-01 03:00:00

Rate of Decline in Alzheimer Disease Measured by a Dementia Severity Rating Scale

Descrição: Objective: To measure clinically relevant change in Alzheimer disease (AD) using a family member-completed Dementia Severity Rating Scale (DSRS) questionnaire. Background: Measuring rate of change provides important clinical information. Most neuropsychologic scores change nonlinearly, complicating their use as a predictor of change throughout the illness. Methods: DSRS and Mini Mental State scores were prospectively collected on 702 patients with AD from first evaluation until they became too impaired to return to clinic. Results: DSRS score increased an average of 4.48 points/y [95% confidence intervel (CI): 4.14-4.82] throughout the entire range of severity. In contrast, the Mini Mental State declined an average of 2.15 points/y (95% CI: 1.85-2.46) during the first 2 years, accelerated to 3.83 points/y (95% CI: 3.28-4.38) during the subsequent 3 years, and then slowed to an annual decline of 1.63 points during the last 2 years (95% CI: 0.21-3.05). A younger age of symptom onset was associated with an increased rate of DSRS change (P=0.03). Conclusions: The DSRS provides a clinical measure of functional impairment in AD that increases about 4.48 points/y from the earliest symptomatic stage until patients become too severely impaired to return to clinic. (C) 2009 Lippincott Williams & Wilkins, Inc.

Seção: Original Articles
Volume: 0
Autor: Xie, Sharon X.; Ewbank, Douglas C.; Chittams, Jesse; Karlawish, Jason H.T.; Arnold, Steven E.; Clark


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