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Differences in Coated-platelet Production Between Frontotemporal... » Isaúde
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Alzheimer Disease and Associated Disorders
2009-07-01 03:00:00

Differences in Coated-platelet Production Between Frontotemporal Dementia and Alzheimer Disease

Descrição: Objective: Coated-platelets are a subset of platelets produced by dual-agonist activation with collagen and thrombin. These platelets retain full-length amyloid precursor protein on their surface and correlate inversely with disease severity in Alzheimer disease (AD). We have now investigated coated-platelet production and its relationship with disease severity in frontotemporal dementia (FTD) patients to determine whether our earlier observations were unique to AD. Methods: Coated-platelet levels were assayed in 40 FTD, 40 AD patients, and 40 controls. Both patient groups were equally divided between mild-stage (Clinical Dementia Rating 1). Results: Coated-platelet levels were not significantly different between patients with early-stage and advanced stage FTD (P=0.9), whereas early-stage AD patients had significantly higher levels than advanced stage AD (P

Seção: Original Articles
Volume: 0
Autor: Prodan, Calin I.; Ross, Elliott D.; Vincent, Andrea S.; Dale, George L.


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