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Alzheimer Disease and Associated Disorders
2019-10-01 05:00:00

Association of TDP-43 Pathology With Domain-specific Literacy in Older Persons

Descrição: Background: Low health and financial literacy may be an early behavioral manifestation of cognitive impairment, dementia, and accumulating Alzheimer pathology. However, there are limited studies investigating the behavioral features associated with hyperphosphorylated transactive response DNA-binding protein-43 (TDP-43), a common age-related pathology, and even fewer studies investigating the neurobiological basis underlying low literacy in aging. Objective: To test the hypothesis that TDP-43 pathology is associated with lower literacy. Materials and Methods: Data came from 293 community-based older persons who were enrolled in 2 ongoing studies of aging. Participants completed literacy and cognitive assessments, consented to brain donation, and underwent detailed neuropathologic evaluation for Alzheimer disease (AD) and TDP-43. Linear regression models assessed the association of TDP-43 with literacy after adjusting for demographics, and AD pathology. Posthoc pairwise comparisons examined whether the level of literacy differed by TDP-43 stage. Results: TDP-43 pathology was associated with lower literacy (estimate=-3.16; SE=0.86; P

Seção: Original Articles
Volume: 0
Autor: Liu, Anran; Sun, Zhaowen; McDade, Eric M.; Hughes, Tiffany F.; Ganguli, Mary; Chang, Chung-Chou H.


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