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Transcranial Direct Current Stimulation Improves Cognitive Function... » Isaúde
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Alzheimer Disease and Associated Disorders
2019-04-01 05:00:00

Transcranial Direct Current Stimulation Improves Cognitive Function in Mild to Moderate Alzheimer Disease: A Meta-Analysis

Descrição: Objective: The purpose of this meta-analysis was to evaluate the therapeutic effect of transcranial direct current stimulation (tDCS) on mild to moderate Alzheimer disease (AD) patients. Materials and Methods: PubMed, Embase, Web of Science, and Cochrane Library were searched until April 2018. The primary cognitive outcomes were extracted from included articles. A crude standardized mean difference with 95% CI was calculated by using fixed or random effect models. Results: Seven studies with 146 patients were included in this meta-analysis. The pooled result showed that tDCS significantly improved cognitive function of AD patients (standardized mean difference=0.37; 95% CI, 0.09-0.65; P=0.01). Subgroup analyses showed that: a single session of tDCS was significantly effective (P0.05) but not higher current density (0.08-mA/cm2) significantly improved cognitive performance; stimulating the temporal cortex (P

Seção: Review Article
Volume: 0
Autor: Han, Jee-young; Besser, Lilah M.; Xiong, Chengjie; Kukull, Walter A.; Morris, John C.


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