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Nutritional Status is Associated With Severe Dementia and Mortality:... » Isaúde
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Alzheimer Disease and Associated Disorders
2018-10-01 05:00:00

Nutritional Status is Associated With Severe Dementia and Mortality: The Cache County Dementia Progression Study

Descrição: Purpose: Studies have reported faster cognitive/functional decline in persons with dementia (PWD) with malnutrition. We investigated whether baseline nutritional status predicted severe dementia and mortality in a population-based sample. Patients: A maximum of 300 PWD were assessed annually for up to 8.6 years. Methods: Nutritional status was assessed using a modified Mini-Nutritional Assessment (mMNA). Severe dementia was defined as: -severe- rating on the Clinical Dementia Rating or Mini-Mental State Examination score -10. Using Cox proportional hazards models, we examined the association between baseline mMNA score (or its subcomponents) with each outcome. Covariates included demographics; dementia onset age, type, and duration; APOE genotype; and residency with caregiver. Results: Compared with -well-nourished,- -malnourished- PWD had 3-4 times the hazard of severe dementia [hazard ratio (HR), 4.31; P=0.014] and death (HR, 3.04; P

Seção: Original Articles
Volume: 0
Autor: Nguyen, Madeline T.; Mattek, Nora; Woltjer, Randy; Howieson, Diane; Silbert, Lisa; Hofer, Scott; Kaye, Jeffrey; Dodge, Hiroko; Erten-Lyons, Deniz


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