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Pathologies Underlying Longitudinal Cognitive Decline in the Oldest Old » Isaúde
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Alzheimer Disease and Associated Disorders
2018-10-01 05:00:00

Pathologies Underlying Longitudinal Cognitive Decline in the Oldest Old

Descrição: Background: Understanding contributions of different brain pathologies to domain-specific cognitive trajectories in the oldest old is crucial to guide future intervention studies. Methods: Two-hundred-twenty Oregon Alzheimer-s Disease Center research participants who were cognitively intact at entry were followed on average for 7.3 years with annual neuropsychological testing until death (mean age, 93.7-y) and autopsy. Mixed effects models examined the relationship between trajectories in memory, verbal fluency, and mini-mental state examination (MMSE) and pathology (neurofibrillary tangles, neuritic plaques, gross infarcts, hippocampal sclerosis, Lewy bodies, APOE genotype, age at death, and years of education). The association between the MMSE trajectory and pathologic variables were examined using a Poisson model with MMSE errors as outcomes given the nonlinear distribution of MMSE scores. Results: Memory trajectory was associated with the APO-4 allele (P=0.006). Verbal fluency trajectory was associated with gross infarcts (P=0.008). MMSE trajectory was associated with high Braak scores (P=0.03), gross infarcts (P

Seção: Original Articles
Volume: 0
Autor: Nguyen, Madeline T.; Mattek, Nora; Woltjer, Randy; Howieson, Diane; Silbert, Lisa; Hofer, Scott; Kaye, Jeffrey; Dodge, Hiroko; Erten-Lyons, Deniz


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