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Coronal CT is Comparable to MR Imaging in Aiding Diagnosis of... » Isaúde
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Alzheimer Disease and Associated Disorders
2018-04-01 05:00:00

Coronal CT is Comparable to MR Imaging in Aiding Diagnosis of Dementia in a Memory Clinic in Singapore

Descrição: Purpose: The present study investigated (a) the agreement between computerized tomography (CT) and 3-T magnetic resonance imaging (MRI) in the visual grading of medial temporal atrophy (MTA); and (b) whether MTA on CT differentiated patients with dementia from no dementia in memory clinics. Materials and Methods: Data were obtained from patients who underwent CT scans at the National University Hospital of Singapore, and from a subsample who subsequently underwent 3-T MRI scans in a research study. Agreements and disagreements between CT and MRI were determined. Area under the curve (AUC) analyses determined if CT-graded MTA distinguished patients with dementia from no dementia. Results: Of the 107 patients in the subsample, MTA scores of 71 agreed on both CT and MRI. The true positive rate between CT and MRI for MTA scores -2 was 79.7%. The true negative rate for MTA scores between 0 and 1 was 96.4%. CT underestimated MTA severity in 33 of 36 disagreements with the MRI. MTA scores -2 on CT distinguished dementia from no dementia in both discovery [n=263; AUC (95% confidence interval)=0.77 (0.72-0.83); sensitivity=0.69; specificity=0.74] and validation [n=264; AUC (95% confidence interval)=0.77 (0.71-0.82); sensitivity=0.72; specificity=0.72] groups. Conclusions: MTA graded on CT is a viable alternative to MRI to aid in the diagnosis of dementia in memory clinics.

Seção: Original Articles
Volume: 0
Autor: Andriuta, Daniela; Moullart, V?ronique; Schraen, Susanna; Devendeville, Agnes; Meyer, Marc-Etienne; Godefroy, Olivier


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