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Regional Cerebral Blood Flow Abnormalities Associated With Apathy and... » Isaúde
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Alzheimer Disease and Associated Disorders
2012-07-01 00:00:00

Regional Cerebral Blood Flow Abnormalities Associated With Apathy and Depression in Alzheimer Disease

Descrição: The aim of this study was to identify brain areas related to apathy or depression in patients with Alzheimer disease (AD). Eighty-one AD patients were enrolled in this prospective study. 99mTc-HMPAO single photon emission computed tomography was performed to evaluate regional cerebral blood flow (rCBF). According to the Neuropsychiatric Inventory subscores of apathy and depression, 9 patients were classified as clinically significant (cs) depressed and non-cs-apathetic (D+) groups and 9 were classified as cs-apathetic and non-cs-depressed (A+) groups. In addition, 18 patients were classified as age-matched and Mini-Mental State Examination-matched disease control groups (D-, A-). The significance of rCBF differences between groups and the correlation between rCBF and subscores in 81 AD patients were estimated by SPM (uncorrected P

Seção: Original Articles
Volume: 0
Autor: Wolfs, Claire A. G.; Kessels, Alfons; Severens, Johan L.; Brouwer, Werner; de Vugt, Marjolein E.; Verhey, Frans R.J.; Dirksen, Carmen D.


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