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Alpha-synuclein in the Cerebrospinal Fluid Differentiates... » Isaúde
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Alzheimer Disease and Associated Disorders
2012-07-01 00:00:00

Alpha-synuclein in the Cerebrospinal Fluid Differentiates Synucleinopathies (Parkinson Disease, Dementia With Lewy Bodies, Multiple System Atrophy) From Alzheimer Disease

Descrição: Background: We examined the utility of quantification of --synuclein (SNCA) in the cerebrospinal fluid (CSF) to differentiate patients with Alzheimer disease (AD), dementia with Lewy bodies (DLB), Parkinson disease (PD), and multiple system atrophy (MSA).Methods: Thirty-seven patients were divided into 4 age-matched and sex-matched clinical groups: AD (n=9), DLB (n=6), PD (n=11), and MSA (n=11). Eleven subjects served as neurological disease controls. The total of 48 subjects included 27 men and 21 women, aged 66.5?11.4 years. We performed a solid-phase sandwich enzyme-linked immunosorbent assay, which enables the sensitive quantification of CSF SNCA.Results: In comparison with controls, CSF SNCA levels in AD were significantly higher (P

Seção: Original Articles
Volume: 0
Autor: Wolfs, Claire A. G.; Kessels, Alfons; Severens, Johan L.; Brouwer, Werner; de Vugt, Marjolein E.; Verhey, Frans R.J.; Dirksen, Carmen D.


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