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NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and... » Isaúde
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Alzheimer Disease and Associated Disorders
2011-12-31 21:00:00

NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons

Descrição: Neural precursor cell expressed, developmentally down-regulated (NEDD9) gene was a new candidate risk gene for Alzheimer disease (AD). The CC genotype of a single nucleotide polymorphism rs760678 within this gene was associated with increasing risk of AD in a large study with white population. Our study aimed to replicate the initial report in Chinese population and explore its effect on cognitive performance. A total of 262 patients with AD, 293 patients with mild cognitive impairment, and 434 cognitive intact controls were recruited in the study. The result showed that G allele had a greater risk of AD (-2 for trend test=5.61, df 1, P=0.018). The effects were mainly observed among Apolipoprotein E (APOE) -4 noncarriers (-2 for trend test=4.30, df 1, P=0.038). After adjustment of sex, age, education year, and APOE -4 status by logistic regression, significant association between NEDD9 GG genotype and AD remained [OR=2.04, 95% confidence interval (CI)=1.02-4.08, P=0.044]. The scores of Cantonese version of the Mini-mental State Examination and Alzheimer-s Disease Assessment Subscale-Cognitive subscale were associated with N polymorphism after adjusting for sex, age, education year, and ApoE -4 status (Linear regression model, P

Seção: Brief Reports
Volume: 0
Autor: Lauterbach, Edward C.


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