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Younger Age at Crisis Following Parental Death in Male Children and... » Isaúde
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Alzheimer Disease and Associated Disorders
2011-12-31 21:00:00

Younger Age at Crisis Following Parental Death in Male Children and Adolescents Is Associated With Higher Risk for Dementia at Old Age

Descrição: Aims: To examine the association of midlife report of crisis following parental death (CFPD) during childhood and adolescence, with dementia at old age.Methods: In 1965, 9362 male participants of the Israel Ischemic Heart Disease study were asked whether they have experienced CFPD (paternal or maternal) during the following ages: 0 to 6, 7 to 12, 13 to 18, or >18 years. Dementia was assessed over 3 decades later in 1889 survivors of the original cohort, 1652 of whom were assessed for CFPD in 1965.Results: Controlling for age, the estimated odds ratios for dementia relative to individuals who reported crisis following paternal parental death (CFPD-P) at the age of 18 years and above were 3.06 (95% CI: 1.42-6.61), 2.15 (95% CI: 0.87-5.31), and 2.35 (95% CI: 1.05-5.28) for those who reported CFPD-P at the ages of 0 to 6, 7 to 12, and 13 to 18 years, respectively. Odds ratios for dementia were 0.60 (95% CI: 0.32-1.11) for participants who reported CFPD-P at ages of 18 and above compared with participants who did not report such a crisis. Similar results were obtained for the association of crisis reported following maternal parental death (CFPD-M) at different age groups and dementia.Conclusions: CFPD during childhood is associated with an increased risk for dementia in men who survived until old age.

Seção: Original Articles
Volume: 0
Autor: Lauterbach, Edward C.


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