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Relation Between Insulin, Insulin-related Factors, and Plasma Amyloid... » Isaúde
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Alzheimer Disease and Associated Disorders
2011-12-31 21:00:00

Relation Between Insulin, Insulin-related Factors, and Plasma Amyloid Beta Peptide Levels at Midlife in a Population-based Study

Descrição: Little is known regarding factors associated with soluble amyloid beta peptide (A-) concentrations in humans at late midlife, when A- is likely most critical to Alzheimer disease pathogenesis. We examined the association between insulin, insulin-related factors, and plasma A- at late midlife. Plasma A-42, A-40, fasting insulin, and c-peptide were measured in 468 women without diabetes, aged 59 to 69 years (median 63 y). Before blood draw, participants reported body mass index, waist circumference, physical activity, alcohol intake, hypertension, and diabetes family history. Linear regression was used to calculate age-adjusted mean differences in A-42 to A-40 ratio, and A-42 levels, by insulin and insulin-related factors. The ratio of A-42 to A-40 was statistically significantly lower in women with family history of diabetes, and A-42 was significantly lower with less physical activity, greater waist circumference, hypertension, and family history of diabetes (P

Seção: Original Articles
Volume: 0
Autor: Lauterbach, Edward C.


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