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Safety and Effectiveness of Donepezil on Behavioral Symptoms in... » Isaúde
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Alzheimer Disease and Associated Disorders
2011-09-30 23:00:00

Safety and Effectiveness of Donepezil on Behavioral Symptoms in Patients With Alzheimer Disease

Descrição: The objective of this study was to evaluate the prevalence and treatment responsiveness of neuropsychiatric symptoms in patients with mild to moderately severe Alzheimer disease recruited in a naturalistic treatment setting in Spain. All the patients, who matched the prescribing recommendations for donepezil and were able to participate in the study, received donepezil (5 to 10 mg/d) for 6 months. The primary outcome measure was the incidence of adverse events. Secondary outcome measures were neuropsychiatric function measured by the Neuropsychiatric Inventory (NPI), the Mini-Mental State Evaluation, and caregiver burden measured by the Zarit scale. Five hundred and twenty-nine patients were included of which 455 completed the study. The mean baseline NPI score was 19.1. Sixty-five patients (12.3%) experienced an adverse event. The most frequent adverse events were diarrhea and agitation (

Seção: Original Articles
Volume: 0
Autor: Bellelli, Giuseppe; Trabucchi, Marco


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