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Microstructural White Matter Abnormalities Independent of White... » Isaúde
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Alzheimer Disease and Associated Disorders
2010-10-01 00:00:00

Microstructural White Matter Abnormalities Independent of White Matter Lesion Burden in Amnestic Mild Cognitive Impairment and Early Alzheimer Disease Among Han Chinese Elderly

Descrição: This study was designed to evaluate the microstructural integrity of white matter (WM) in amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD) among Han Chinese elderly using diffusion tensor imaging (DTI) technique, and to investigate the relationship between WM abnormalities and cognitive dysfunction. Sixty-four subjects (23 mild probable AD, 20 amnestic MCI, and 21 age-matched normal controls) who did not have visible WM lesion burden were analyzed. Fractional anisotropy (FA) and mean diffusivity were measured in normal-appearing WM (NAWM) using DTI with 64 encoding directions. The results were correlated with the scores of Mini-Mental State Examination (MMSE) and Cognitive Ability Screening Instrument (CASI). Statistical analysis showed the FA value in parietal WM was significantly lower in MCI compared to NC (P

Seção: Original Articles
Volume: 0
Autor: Gong, Gordon; O\'Bryant, Sid E.


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