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Ethinylestradiol30ug-drospirenone and metformin: could this... » Isaúde
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BMC Endocrine Disorders
2012-06-20 04:47:14

Ethinylestradiol30ug-drospirenone and metformin: could this combination improve endothelial dysfunction in polycystic ovary syndrome?

Descrição: Background:We are hereby investigating for the first time the effect of the association ethinylestradiol30-g-drospirenone 3mg (DRP/EE30-g) plus metformin and weight loss on endothelial status and C-reactive protein (hsCRP) levels in polycystic ovary syndrome (PCOS).Methods:25 young women with PCOS (mean age 22.76-?-0.83 years, body mass index (BMI): 28.44-?-6.23) who completed the study were prospectively evaluated. The oral contraceptive- DRP/EE30-g (21 days/month) and metformin (1700 mg daily) were administered for 6 months to the PCOS group. Additionally, the 15 overweight and obese patients (BMI->-25 kg/m2) were instructed in a diet of no more than 1500 cal daily. Primary outcome measures were surrogate markers of cardiovascular disease and included endothelial function, i.e. flow-mediated dilatation (FMD) on the brachial artery and endothelin-1 levels, as well as hsCRP concentrations, body composition (measured by whole-body dual-energy X-ray-absorptiometry) and insulin resistance. Variables were assessed at baseline, as well as after our medical intervention.Results:The combination between DRP/EE30-g plus metformin combined with weight loss triggered a significant improvement in the FMD values (FMD-PCOSbasal 3.48-?-1.00 vs FMD-PCOS6 months7.43-?-1.04, p-=-0.033), as well as body composition and insulin insensitivity (p-

Identificador: doi:10.1186/1472-6823-12-9
Volume: 0
Página: 9 a


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