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Changes in the vitamin D endocrine system and bone turnover after... » Isaúde
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BMC Endocrine Disorders
2012-06-14 04:54:11

Changes in the vitamin D endocrine system and bone turnover after oral vitamin D3 supplementation in healthy adults: results of a randomised trial

Descrição: Background:There is uncertainty as to which intake of vitamin D is needed to suppress PTH and maintain normal bone metabolism throughout winter at northern latitudes. We aimed to investigate whether four weeks- daily supplementation with 10--g vitamin D3 from fish oil produced a greater change in serum vitamin D metabolites, parathyroid hormone, and bone turnover in healthy adults compared with solid multivitamin tablets. Furthermore, it was studied whether age, gender, ethnic background, body mass index, or serum concentrations at baseline predicted the magnitude of change in these parameters.Methods:Healthy adults aged 19-48-years living in Oslo, Norway (59?N) were randomised to receive a daily dose of 10--g vitamin D3 given as fish oil capsules or multivitamin tablets during four weeks in late winter. Serum samples from baseline and after 28-days were analysed for 25-hydroxyvitamin D (s-25(OH)D), 1,25-dihydroxyvitamin D (s-1,25(OH)2D), intact parathyroid hormone (s-iPTH), and osteoclast-specific tartrate-resistant acid phosphatase 5b (s-TRACP). Fifty-five eligible participants completed the intervention (74% of those randomised).Results:S-25(OH)D increased by mean 34.1 (SD 13.1) nmol/l, p-

Identificador: doi:10.1186/1472-6823-12-7
Volume: 0
Página: 7 a

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