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Effects of omega-6/3 and omega-9/6 nutraceuticals on pain and... » Isaúde
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Acta Cirurgica Brasileira
0000-00-00 00:00:00

Effects of omega-6/3 and omega-9/6 nutraceuticals on pain and fertility in peritoneal endometriosis in rats

Descrição: Abstract Purpose: To evaluate the effects of the nutraceuticals omega-6/3 and omega-9/6 on endometriosis-associated infertility and pain. Methods: Controlled experimental study, with each group composed of eight female rats. Fertility groups: sham-operated control (0.9% saline solution); control with endometriosis (0.9% saline); omega-6/3 (1.2 g/kg/day); omega-9/6 (1.2 g/kg/day); and meloxicam (0.8 mg/kg/day). Pain groups: sham-operated control (0.9% saline); control with endometriosis (0.9% saline); omega-6/3 (1.2 g/kg/day); omega-9/6 (1.2 g/kg/day); medroxyprogesterone acetate (5 mg/kg/every 3 days); and meloxicam (0.8 mg/kg/day). Peritoneal endometriosis was surgically induced. Pain was evaluated with the writhing test. Fertility was evaluated by counting the number of embryos in the left hemi-uterus. Results: The mean number of writhings was as follows: sham-operated, 11.1 ? 2.9; control with endometriosis, 49.3 ? 4.4; omega-6/3, 31.5 ? 2.7; omega-9/6, 34.1 ? 4.5; medroxyprogesterone acetate, 2.1 ? 0.8; meloxicam, 1 ? 0.3. There was a significant difference between both controls and all drugs used for treatment. Regarding fertility, the mean values were as follows: sham-operated, 6.8 ? 0.6; control with endometriosis, 4.2 ? 0.7; omega-6/3, 4.7 ? 1; omega-9/6, 3.8 ? 0.9; and meloxicam, 1.8 ? 0.9. Conclusions: The omega-6/3 and omega-9/6 nutraceuticals decreased pain compared to the controls. There was no improvement in fertility in any of the tested groups.

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