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Epigenetic changes by DNA methylation in chronic and intermittent... » Isaúde
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American Journal of Physiology - Lung Cellular and Molecular Physiology
2017-12-01 11:30:24

Epigenetic changes by DNA methylation in chronic and intermittent hypoxia

Descrição: DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high-altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation. This article presents a brief update on emerging evidence suggesting that changes in DNA methylation contribute to pathologies caused by chronic IH and potentially mediate adaptations to chronic sustained hypoxia by affecting the hypoxia-inducible factor (HIF) signaling pathway.

Editorial: American Physiological Society
Número: 6
Volume: 313
Página: L1096 a L1100
Autor: Nanduri, J., Semenza, G. L., Prabhakar, N. R.

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