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Meta-analysis: polymorphisms in TNF-α gene promoter and... » Isaúde
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Alimentary Pharmacology and Therapeutics
2010-04-29 14:06:00

Meta-analysis: polymorphisms in TNF-α gene promoter and Crohn's disease

Descrição: Aliment Pharmacol Ther 2010; 32: 159[ndash]170Background Tumour necrosis factor alpha (TNF-[alpha]) is involved in the pathogenesis of Crohn's disease (CD). However, results on the association between the polymorphisms in TNF-[alpha] promoter and the risk of CD are inconsistent.Aim To perform a quantitative synthesis for the genetic polymorphisms in TNF-[alpha] promoter and CD risk.Methods Databases were searched (up to 2009) and 31 studies were included. Risks of CD associated with the polymorphisms in TNF-[alpha] promoter were assessed.Results Overall, individuals with -1031 TC+CC genotype had a slightly increased risk to develop CD compared with individuals with -1031 TT genotype (OR, 1.32; 95% CI, 1.03[ndash]1.70). In the further stratified analysis, we found Asians with the -1031T>C, -863 C>A and -857 C>T variant polymorphisms have almost one and a half CD risk compared with other genotypes (OR, 1.58; 95% CI, 1.16[ndash]2.15; OR, 1.55; 95% CI, 1.18[ndash]2.02; OR, 1.54; 95% CI, 1.19[ndash]1.99 respectively). We did not find -308 G>A variant associated with CD location and disease behaviours in stratified analysis.Conclusions TNF-[alpha] polymorphisms in the promoter region might be used as a biomarker for CD risk prediction. Larger studies with mixed ethnicity subjects and stratified by clinical and sub clinical characteristics are needed to validate our findings.

Identificador: 10.1111/j.1365-2036.2010.04340.x
Editorial: John Wiley & Sons, Inc.
Seção: Meta-analysis
Volume: 0
Página: 159 a 170
Autor: Z. Han, C. Li, S. Han, Y. Han, J. Qiu, Y. Shi, J. Wang, A. Sun, J. Ding, K. Wu, D. Fan

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