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Meta-analysis: pre-operative infliximab treatment and short-term... » Isaúde
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Alimentary Pharmacology and Therapeutics
2009-11-19 10:37:00

Meta-analysis: pre-operative infliximab treatment and short-term post-operative complications in patients with ulcerative colitis

Descrição: Aliment Pharmacol Ther 31, 486[ndash]492Background Infliximab was approved for use in ulcerative colitis in recent years. It has been debated if infliximab increases the risk of post-operative complications in patients with ulcerative colitis.Aim To perform a meta-analysis that examines the relationship between preoperative infliximab treatment and short-term post-operative complications in patients with ulcerative colitis.Methods We searched the PubMed and MEDLINE databases to identify observational studies on the impact of pre-operative infliximab use on short-term post-operative complications in ulcerative colitis. Infectious complications mainly included wound infection, sepsis and abscess, whereas non-infectious complications included intestinal obstruction, thromboembolism and gastrointestinal haemorrhage. Pooled odds ratios (ORs) were calculated for each relationship.Results A total of 5 studies and 706 patients were included in our meta-analysis. Overall, we did not find a strong association between pre-operative treatment of infliximab and short-term infectious [OR 2.24, 95% confidence interval (CI) 0.63[ndash]7.95] or non-infectious (OR 0.85, 95% CI 0.50[ndash]1.45) post-operative complications in ulcerative colitis patients. On the contrary, we discovered that pre-operative infliximab use increased short-term total post-operative complications (OR 1.80, 95% CI 1.12[ndash]2.87).Conclusions Pre-operative infliximab use increased the risk of short-term post-operative complications. Subgroup analysis is underpowered to assess the nature of these complications but shows a trend towards increased post-operative infection.

Identificador: 10.1111/j.1365-2036.2009.04204.x
Editorial: John Wiley & Sons, Inc.
Seção: Meta-analysis
Volume: 0
Página: 486 a 492
Autor: Z. YANG, Q. WU, K. WU, D. FAN


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