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Meta-analysis: the association of hepatitis B virus genotypes and... » Isaúde
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Alimentary Pharmacology and Therapeutics
2013-01-11 03:00:29

Meta-analysis: the association of hepatitis B virus genotypes and hepatocellular carcinoma

Descrição: BackgroundA meta-analysis on the risk of hepatocellular carcinoma (HCC) among hepatitis B virus (HBV) genotypes is warranted as the current data are conflicting.AimTo investigate the relative risk of HCC among the four major HBV genotypes (A-D).MethodsA meta-analysis was performed based on literature search from electronic databases and bibliography between 1950 and 2012. All abstracts with keywords -hepatitis B-, -hepatocellular carcinoma- and -genotype- were screened. Studies were included if they reported HBV genotype as an exposure and HCC as an outcome.ResultsNine hundred and eighty-eight abstracts were found through literature search, among them 43 studies were eligible for this meta-analysis. A total of 14?545 patients with an average age of 43?years were included; 71% were male patients and 17% had cirrhosis. In 33 studies, HCC was found in 1541/6060 (25%) genotype C vs. 550/4417 (12%) genotype B HBV-infected patients [odds ratio (OR)?=?2.05, 95% confidence interval (CI)?=?1.52-2.76, P?

Editorial: John Wiley & Sons, Inc.
Seção: Meta-analysis
Volume: 0
Página: 517 a 526


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