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Meta-analysis: oral bisphosphonates and the risk of oesophageal cancer » Isaúde
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Alimentary Pharmacology and Therapeutics
2012-09-12 03:40:18

Meta-analysis: oral bisphosphonates and the risk of oesophageal cancer

Descrição: BackgroundBisphoshonates, which are used in the treatment and prevention of osteoporosis, have recently been implicated in the development of oesophageal cancer; however, studies report conflicting data.AimTo conduct a meta-analysis of studies reporting on the association between bisphosphonates and oesophageal cancer to quantify the relationship.MethodsA search was conducted through Medline, PubMed, Embase and Current Contents Connect to 2 August 2012. We calculated pooled odds ratios and 95% CIs using a random effects model for the risk of oesophageal cancer associated with exposure to bisphosphonates, as well as for the different periods of exposure.ResultsSeven studies, with 19?700 oesophageal cancer cases, met our inclusion criteria. We found a positive relationship between exposure to bisphosphonates and oesophageal cancer, with an odds ratio (OR) of 1.74 with a 95% CI of 1.19-2.55. Heterogeneity was observed (I2?=?85%, P?

Editorial: John Wiley & Sons, Inc.
Seção: Meta-analysis
Volume: 0
Página: 708 a 716


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