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Meta-analysis: IL-28B genotype and sustained viral clearance in HCV... » Isaúde
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Nome da revista:   Volume:   Número:
Alimentary Pharmacology and Therapeutics
2012-05-22 04:05:27

Meta-analysis: IL-28B genotype and sustained viral clearance in HCV genotype 1 patients

Descrição: BackgroundPolymorphisms in the IL-28B region are a strong predictor of sustained virologic response (SVR) in individual studies of HCV genotype 1 patients receiving peginterferon (pegIFN) and ribavirin.AimTo obtain a pooled odds ratio (OR) of SVR in patients of varying race with the favourable IL-28B genotype compared to those with the unfavourable genotype.MethodsA literature search was conducted using online databases and a review of conference abstracts. A random effects meta-analysis was performed and study heterogeneity and publication bias were assessed.ResultsThere were 21 individual studies of HCV genotype 1 patients of varying ethnicity treated with pegIFN and ribavirin. The pooled prevalence of the favourable IL-28B genotype varied by race (73% vs. 41% vs. 13% in 2612 Asians, 3110 Caucasians and 452 African-Americans, respectively, P?

Editorial: John Wiley & Sons, Inc.
Seção: Meta-analysis
Volume: 0
Página: 104 a 114

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