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Meta-analysis: vasoactive medications for the management of acute... » Isaúde
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Alimentary Pharmacology and Therapeutics
2012-04-09 00:53:13

Meta-analysis: vasoactive medications for the management of acute variceal bleeds

Descrição: BackgroundVasoactive medications such as vasopressin, somatostatin and their analogues (terlipressin, vapreotide and octreotide) are commonly used for the treatment of acute variceal bleeding. However, the risks and benefits of these interventions are not well understood.AimTo undertake a meta-analysis of the efficacy of vasoactive medications in patients having acute variceal bleeds.MethodsRandomised controlled trials (RCTs) of vasopressin, somatostatin and their analogues, administered to patients with acute variceal bleeds were identified based on systematic searches of nine electronic databases and multiple sources of grey literature.ResultsThe search identified 3011 citations, and 30 trials with a total of 3111 patients met eligibility criteria. The use of vasoactive agents was associated with a significantly lower risk of 7-day mortality (RR 0.74; 95% CI 0.57-0.95; P?=?0.02; I2?=?0%; moderate quality of evidence), and a significant improvement in haemostasis (RR 1.21, 95% CI 1.13-1.30; P?

Editorial: John Wiley & Sons, Inc.
Seção: Meta-analysis
Volume: 0
Página: n/a a n/a


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