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Lateral gene transfer of an ABC transportercomplex between major... » Isaúde
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BMC microbiology [electronic resource]
2012-11-02 02:07:10

Lateral gene transfer of an ABC transportercomplex between major constituents of the humangut microbiome

Descrição: Background:Several links have been established between the human gut microbiome and conditions suchas obesity and inflammatory bowel syndrome. This highlights the importance ofunderstanding what properties of the gut microbiome can affect the health of the human host.Studies have been undertaken to determine the species composition of this microbiome andinfer functional profiles associated with such host properties. However, lateral gene transfer(LGT) between community members may result in misleading taxonomic attributions for therecipient organisms, thus making species-function links difficult to establish.Results:We identified a peptides/nickel transport complex whose components differed in abundancebased upon levels of host obesity, and assigned the encoded proteins to members of themicrobial community. Each protein was assigned to several distinct taxonomic groups, withmoderate levels of agreement observed among different proteins in the complex.Phylogenetic trees of these proteins produced clusters that differed greatly from taxonomicattributions and indicated that habitat-directed LGT of this complex is likely to haveoccurred, though not always between the same partners.Conclusions:These findings demonstrate that certain membrane transport systems may be an importantfactor within an obese-associated gut microbiome and that such complexes may be acquiredseveral times by different strains of the same species. Additionally, an example of individualproteins from different organisms being transferred into one operon was observed, potentiallydemonstrating a functional complex despite the donors of the subunits being taxonomicallydisparate. Our results also highlight the potential impact of habitat-directed LGT on theresident microbiota.

Identificador: doi:10.1186/1471-2180-12-248
Volume: 0
Página: 2 a

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