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Zinc-induced envelope stress diminishes type III secretion in... » Isaúde
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BMC microbiology [electronic resource]
2012-06-25 03:28:12

Zinc-induced envelope stress diminishes type III secretion in enteropathogenic Escherichia coli

Descrição: Background:Dietary supplementation with zinc has been shown to reduce the duration and severity of diarrhoealdisease caused by Enteropathogenic Escherichia coli, common in infants in developing countries. Initially thistherapeutic benefit was attributed to the correction of zinc deficiency in malnourished individuals, but recentlyevidence has emerged that zinc significantly impacts the pathogens themselves: zinc concentrations achievableby oral supplementation can reduce the expression of key virulence-related genes in EPEC and related organisms.Results:Here, we investigate three possible mechanisms for such zinc-induced changes in expression of EPECvirulence: direct interaction of zinc with regulators of LEE operons; genetic interaction of LEE operons withknown regulators of zinc homeostasis; and finally, downregulation of LEE transcription associated withactivation of the ?E envelope stress response by zinc. We find evidence only for the latter mechanism, includingzinc-induced down-regulation of Type III secretion in EPEC similar to that caused by ammonium metavanadate,another known inducer of the ?E stress response.Conclusions:We conclude therefore that envelope stress is a major mechanism by which zinc attenuates thevirulence of EPEC and related pathogens.

Identificador: doi:10.1186/1471-2180-12-123
Volume: 0
Página: 1 a


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