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An important role of interleukin-10 in counteractingexcessive immune... » Isaúde
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BMC microbiology [electronic resource]
2012-06-09 03:33:10

An important role of interleukin-10 in counteractingexcessive immune response in HT-29 cells exposed toClostridium butyricum

Descrição: Background:Clostridium butyricum has become increasingly important in preventing and treatingintestinal inflammation. In the intestine it may increase the resistance of the gut to pathogeninvasion via inducing the secretion of anti-inflammatory cytokines. Interleukin 10 (IL-10)plays a central role in preventing certain inflammatory diseases by down-regulatinginflammatory cascades. In a previous study, we observed that the level of IL-10 mRNA wasmodulated by C. butyricum. The aim of this study was to investigate whether C. butyricumachieves its beneficial effects through IL-10.Results:We treated HT-29 cells with anti-IL-10 (IL-10 antibody) or siIL-10 (IL-10 small interferingRNA) to disrupt IL-10. In both cases, the effects of C. butyricum-induced NF-kappaB activationand IL-8 expression were enhanced. We also found that neutralization or knockdown of IL-10 could induce apoptosis and necrosis of HT-29 cells treated with C. butyricum comparedwith control cells.Conclusions:These findings show that IL-10 serves an important role in C. butyricum-mediated immuneprotection, and in host recognition of C. butyricum.

Identificador: doi:10.1186/1471-2180-12-100
Volume: 0
Página: 1 a


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