A PHP Error was encountered

Severity: Warning

Message: Creating default object from empty value

Filename: models/publicacao_item.php

Line Number: 20

Unbalance of intestinal microbiota in atopic children » Isaúde
  Pesquisar Publicações Científicas  
  Especialidade: carregando especialidades...  Carregando...
Nome da revista:   Volume:   Número:
BMC microbiology [electronic resource]
2012-06-07 03:35:04

Unbalance of intestinal microbiota in atopic children

Descrição: Background:Playing a strategic role in the host immune function, the intestinal microbiota has beenrecently hypothesized to be involved in the etiology of atopy. In order to investigate thegastrointestinal microbial ecology of atopic disease, here we performed a pilot comparativemolecular analysis of the faecal microbiota in atopic children and healthy controls.Results:Nineteen atopic children and 12 healthy controls aged 4-14 years were enrolled. Stools werecollected and the faecal microbiota was characterized by means of the already developedphylogenetic microarray platform, HTF-Microbi.Array, and quantitative PCR. The intestinalmicrobiota of atopic children showed a significant depletion in members of the Clostridiumcluster IV, Faecalibacterium prausnitzii, Akkermansia muciniphila and a correspondingincrease of the relative abundance of Enterobacteriaceae.Conclusion:Depleted in key immunomodulatory symbionts, the atopy-associated microbiota canrepresent an inflammogenic microbial consortium which can contribute to the severity of thedisease. Our data open the way to the therapeutic manipulation of the intestinal microbiota inthe treatment of atopy by means of pharmaceutical probiotics.

Identificador: doi:10.1186/1471-2180-12-95
Volume: 0
Página: 9 a


Mais informações

  • Twitter iSaúde
publicidade
Jornal Informe Saúde

Indique o portal
Fechar [X]
  • Você está indicando a notícia: http://www.isaude.net
  • Para que seu amigo(a) receba esta indicação preencha os dados abaixo:

RSS notícias do portal  iSaúde.net
Receba o newsletter do portal  iSaúde.net
Indique o portal iSaúde.net
Notícias do  iSaúde.net em seu blog ou site.
Receba notícias com assunto de seu interesse.
© 2000-2011 www.isaude.net Todos os direitos reservados.