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Unbalance of intestinal microbiota in atopic children » Isaúde
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BMC microbiology [electronic resource]
2012-06-07 03:35:04

Unbalance of intestinal microbiota in atopic children

Descrição: Background:Playing a strategic role in the host immune function, the intestinal microbiota has beenrecently hypothesized to be involved in the etiology of atopy. In order to investigate thegastrointestinal microbial ecology of atopic disease, here we performed a pilot comparativemolecular analysis of the faecal microbiota in atopic children and healthy controls.Results:Nineteen atopic children and 12 healthy controls aged 4-14 years were enrolled. Stools werecollected and the faecal microbiota was characterized by means of the already developedphylogenetic microarray platform, HTF-Microbi.Array, and quantitative PCR. The intestinalmicrobiota of atopic children showed a significant depletion in members of the Clostridiumcluster IV, Faecalibacterium prausnitzii, Akkermansia muciniphila and a correspondingincrease of the relative abundance of Enterobacteriaceae.Conclusion:Depleted in key immunomodulatory symbionts, the atopy-associated microbiota canrepresent an inflammogenic microbial consortium which can contribute to the severity of thedisease. Our data open the way to the therapeutic manipulation of the intestinal microbiota inthe treatment of atopy by means of pharmaceutical probiotics.

Identificador: doi:10.1186/1471-2180-12-95
Volume: 0
Página: 9 a

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