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Anterior Keratocyte Depletion in Fuchs Endothelial Dystrophy... » Isaúde
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Archives of ophthalmology
2011-05-09 19:51:34

Anterior Keratocyte Depletion in Fuchs Endothelial Dystrophy [Clinical Sciences]

Assunto: Ophthalmology, Ophthalmological Disorders, Corneal Disorders, Ophthalmological Procedures, Surgical Procedures, Ophthalmological Procedures, Other, Transplantation, Transplantation, Other

Descrição: Objective  To determine if keratocyte populations are different in corneas with Fuchs dystrophy compared with control corneas.Methods  Eleven corneas excised during penetrating keratoplasty for Fuchs dystrophy and 5 control corneas of eyes enucleated for choroidal melanoma were examined using light microscopy. Twenty control corneas age-matched to the corneas with Fuchs dystrophy were examined using confocal microscopy in vivo. The number of keratocytes in a full-thickness column of central stroma with frontal area of 1 mm2, determined using histologic and confocal methods, was compared between corneas with Fuchs dystrophy and controls.Results  By histology, the mean (SD) number of cells in a full-thickness column of stroma in Fuchs dystrophy (12 215 [1394] cells) was less than in control corneas (15 628 [710] cells; P < .001). The mean (SD) number of keratocytes in the anterior 10% of the stroma of corneas with Fuchs dystrophy (682 [274] cells) was less than in the control corneas measured using histology (1858 [404] cells; P < .001) and confocal microscopy (1481 [397] cells; P < .001).Conclusions  Keratocytes are depleted by 54% to 63% in the anterior 10% of the stroma of corneas that require penetrating keratoplasty for Fuchs dystrophy. Keratocyte loss might contribute to anterior stromal changes that persist and degrade vision after endothelial keratoplasty.

Identificador: i
Editorial: American Medical Association
Seção: Clinical Sciences
Número: 5
Volume: 129
Página: 555 a 561
Autor: Hecker, L. A., McLaren, J. W., Bachman, L. A., Patel, S. V.


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