Descrição: T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive and heterogeneous malignancy originating from T-cell precursors. The mechanisms of T-ALL pathogenesis related to non-protein coding part of the genome are currently intensively studied. miRNAs are short, non-coding molecules acting as negative regulators of gene expression which shape phenotype of cells in a complex and context-specific manner. miRNAs may act as oncogenes or tumor suppressors; several miRNAs have been related to drug resistance and treatment response in various malignancies.
Identificador: 10.1016/j.blre.2018.04.003
Seção: Review
Volume: 0
Página: 457 a 472
Autor: Monika Drobna, Bronis-awa Szarzy-ska-Zawadzka, Ma-gorzata Dawidowska
