A PHP Error was encountered

Severity: Warning

Message: Creating default object from empty value

Filename: models/publicacao_item.php

Line Number: 20

Cutaneous Melanoma and Endogenous Hormonal Factors: A Large French... » Isaúde
  Search scientific publications  
  Especialidade: carregando especialidades...  Loading...
Name of the journal:   Volume:   Number:
American journal of epidemiology
2011-05-03 21:37:44

Cutaneous Melanoma and Endogenous Hormonal Factors: A Large French Prospective Study

Description: To assess the role of endogenous hormonal factors on melanoma, the authors conducted a prospective analysis of 91,972 French women, aged 40–65 years at inclusion into the Etude Epidémiologique auprès de femmes de l’Education Nationale (E3N) cohort. Between 1990 and 2005, 460 melanoma cases were ascertained. Relative risks and 95% confidence intervals were computed by using Cox proportional hazards regression models. Risks of melanoma were reduced in women with ≥15 years at menarche (relative risk (RR) = 0.67, 95% confidence interval (CI): 0.46, 0.97, compared with 13–14 years), irregular menstrual cycles (RR = 0.52, 95% CI: 0.31, 0.89, compared with regular cycles of 25–31 days), <48 years at natural menopause (RR = 0.70, 95% CI: 0.48, 1.02, compared with 48–51 years), and shorter ovulatory life (RR = 0.51, 95% CI: 0.28, 0.91, for <33 years compared with ≥39 years). Modest inverse associations were observed with parity, as well as number of pregnancies and miscarriages. There was no evidence of an association between melanoma risk and age at first birth or pregnancy, age at last birth, time since last birth, breastfeeding duration, age at menstruation regularity, or menopausal status. Results did not significantly differ according to ambient ultraviolet radiation dose and melanoma site or subtype. These findings from a large prospective cohort may suggest a reduced melanoma risk associated with decreased exposure to ovarian hormones.

Identifier: i
Editorial: Oxford University Press
Section: RESEARCH-ARTICLE
Number: 10
Volume: 173
Page: 1192 a 1202
Author: Kvaskoff, M., Bijon, A., Mesrine, S., Boutron-Ruault, M.-C., Clavel-Chapelon, F.


More info

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.