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Specific IgE response to different grass pollen allergen components... » Isaúde
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Name of the journal:   Volume:   Number:
Clinical and Molecular Allergy
2012-06-14 05:06:15

Specific IgE response to different grass pollen allergen components in children undergoing sublingual immunotherapy

Description: Background:Grass pollen is a major cause of respiratory allergy worldwide and contain a number of allergens, some of theme (Phl p 1, Phl p 2, Phl p 5, and Phl 6 from Phleum pratense, and their homologous in other grasses) are known as major allergens. The administration of grass pollen extracts by immunotherapy generally induces an initial rise in specific immunoglobulin E (sIgE) production followed by a progressive decline during the treatment. Some studies reported that immunotherapy is able to induce a de novo sensitisation to allergen component previously unrecognized.Methods:We investigated in 30 children (19 males and 11 females, mean age 11.3 years), 19 treated with sublingual immunotherapy (SLIT) by a 5-grass extract and 11 untreated, the sIgE and sIgG4 response to the different allergen components.Results:Significant increases (p-

Identifier: doi:10.1186/1476-7961-10-7
Volume: 0
Page: 7 a


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