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[Clinical Picture] Listeria endophthalmitis in a patient receiving... » Isaúde
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Lancet Infectious Diseases
2019-08-01 00:00:00

[Clinical Picture] Listeria endophthalmitis in a patient receiving immunomodulatory therapy

Description: A 68-year-old man with metastatic melanoma was admitted to our hospital with listeria endophthalmitis in April, 2018. The patient had started 21-day cycles of nivolumab (1 mg/kg) and ipilimumab (3 mg/kg) in January, 2017. In April, 2017, because of concerns that adrenal insufficiency and hypothyroidism were off target immune effects, ipilimumab treatment was stopped and nivolumab treatment was increased to 3 mg/kg until December, 2017, when the patient developed diarrhoea. He subsequently received infliximab (single dose 5 mg/kg) and intravenous methylprednisolone 100 mg twice a day for 3 days, followed by an oral taper over 3 weeks for autoimmune colitis.

Identifier: 10.1016/S1473-3099(19)30108-2
Section: Clinical Picture
Number: 8
Volume: 19
Page: 913 a
Author: Chuen-Yen Lau, Seble G Kassaye

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