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Kidney Transplantation in Monoclonal Immunoglobulin Deposition... » Isaúde
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American Journal of Kidney Diseases
2021-05-04 00:00:00

Kidney Transplantation in Monoclonal Immunoglobulin Deposition Disease: A Report of 6 Cases

Description: Monoclonal immunoglobulin deposition disease (MIDD) usually leads to kidney failure. Treatment of patients with a bortezomib-based regimen followed by autologous stem cell transplantation has been increasingly used, with improvements in the response rates and the allograft outcomes in kidney transplant recipients. The objective of this report was to analyze the outcomes of 6 patients who underwent kidney transplantation in our institution after treatment of MIDD between 2010 and 2019. Monoclonal immunoglobulin deposition disease was initially treated with Bortezomib-based therapy followed by high dose melphalan and autologous stem cell transplant (SCT) with complete hematologic response, although all patients remained on dialysis.

Identifier: 10.1053/j.ajkd.2021.02.337
Section: Case Reports
Volume: 0
Author: Alicia Molina-And?jar, Natalia Tovar, Elena Cuadrado, Natalia Castrej?n de Anta, Ignacio Revuelta, David Cucchiari, Frederic Cofan, N?ria Esforzado, M. Teresa Cibeira, Laura Rosi?ol, Joan Blad?, Fritz Diekmann, Carlos Fern?ndez de Larrea, Luis F. Qui


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