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Proliferative Glomerulonephritis With Fibrils, Monoclonal - Light... » Isaúde
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American Journal of Kidney Diseases
2021-03-24 00:00:00

Proliferative Glomerulonephritis With Fibrils, Monoclonal - Light Chain, and C3 Deposits

Description: There is increasing recognition of monoclonal gammopathy as a cause of proliferative glomerulonephritis (GN), including cases in which glomerular deposition of monoclonal immunoglobulin (mIg) is demonstrated. Recently, proliferative GN with mIg deposits (PGNMID) has incorporated a light chain (LC) variant of the disease (termed PGNMID-LC). Intriguingly, glomerular co-deposition of complement C3 is found in addition to monotypic LC, implying complement activation via the alternative pathway (AP).

Identifier: 10.1053/j.ajkd.2021.01.014
Section: Case Reports
Volume: 0
Author: Adam G. STEINBERG, Lucy C. FOX, Sebastien BENDER, Ahida BATROUNEY, Surender JUNEJA, Christophe SIRAC, Guy TOUCHARD, Piers BLOMBERY, Moira J. FINLAY, Frank BRIDOUX, Thomas D. BARBOUR

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