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Successful Treatment of Patients With Refractory PLA2R-Associated... » Isaúde
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American Journal of Kidney Diseases
2020-04-17 00:00:00

Successful Treatment of Patients With Refractory PLA2R-Associated Membranous Nephropathy With Obinutuzumab: A Report of 3 Cases

Description: Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Rituximab, a type I anti-CD20 antibody, has been shown to be an effective therapy in treatment of patients with MN associated with M-type phospholipase A2 receptor (PLA2R) antibodies. Despite its effectiveness up to 40% of patients may fail to respond to rituximab, which may be related to higher PLA2R antibody titers. Obinutuzumab, a type II anti-CD20 depleter, has been shown to produce a more profound CD20 depletion and be more efficacious in treating certain hematological malignancies compared to rituximab.

Identifier: 10.1053/j.ajkd.2020.02.444
Section: Case Reports
Volume: 0
Author: Nattawat Klomjit, Fernando C. Fervenza, Ladan Zand


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