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Fundus Autofluorescence in Autosomal Dominant Occult Macular... » Isaúde
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Name of the journal:   Volume:   Number:
Archives of ophthalmology
2011-05-09 19:51:34

Fundus Autofluorescence in Autosomal Dominant Occult Macular Dystrophy [Clinical Sciences]

Subject: Ophthalmology, Ophthalmological Disorders, Macular Disorders, Ophthalmological Procedures, Ocular Imaging, Genetics, Genetic Disorders

Description: Objective  To characterize fundus autofluorescence (FAF) images of eyes with autosomal dominant occult macular dystrophy (OMD).Methods  All patients received a comprehensive ophthalmologic examination for diagnosis of OMD. We evaluated the FAF images in 13 eyes of 7 patients with autosomal dominant OMD by confocal scanning laser ophthalmoscopy with excitation at 488 nm and emission more than 500 nm.Results  The FAF images showed unspecific weak foveal hyperfluorescence in 4 eyes of 2 patients; one showed a thin hyperfluorescence in the temporal fovea bilaterally and the other showed weak hyperfluorescence in the fovea bilaterally. The optical coherence tomographic images showed abnormalities of the photoreceptor inner segment–outer segment line and cone outer segment tip line in all patients. However, 5 patients had normal FAF images regardless of morphological abnormalities of the photoreceptor.Conclusions  Fundus autofluorescence is a useful method to acquire additional information of photoreceptor/retinal pigment epithelium function in eyes with OMD. Fundus autofluorescence will be also helpful for the differential diagnosis of eyes with OMD vs eyes with other dystrophies that have a distinctive FAF pattern.

Identifier: i
Editorial: American Medical Association
Section: Clinical Sciences
Number: 5
Volume: 129
Page: 597 a 602
Author: Fujinami, K., Tsunoda, K., Hanazono, G., Shinoda, K., Ohde, H., Miyake, Y.


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