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publicado em 02/08/2010 às 21h00:00
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Microfluidic HIV test detects and monitors the infection quickly

Device may make HIV testing more accessible in the developing world and other regions with few resources

 
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A new device for rapid diagnosis and monitoring of HIV infection has been developed by biomedical engineer at the University of California, USA, Alexander Revzin. The device can make HIV testing more accessible in the developing world and in poor countries.

The new test consists of a polymer film printed with a dot matrix in miniature. Each section contains specific antibodies to two types of T cells, white blood cells affected by HIV, and three kinds of cytokines, proteins released by inflammatory T cells When blood flows through the points with antibodies, T cells, CD4 and CD8, becoming attached to them. Cytokines are picked up by other parts of the film.

A system of free imaging lens is used to quickly count the number of T cells, the CD4/CD8 ratio and measure the cytokines secreted.

The test results reaches six to 12 times faster than traditional approaches and tests six parameters simultaneously, using a small blood sample.

"With further development, the device could be the basis for blood tests in the developing world and in areas poor in resources," according to Revzin.

"In addition to testing and monitoring of HIV, this device will be useful for blood transfusions where the blood safety is often at issue," he said. "It could also be modified to directly detect HIV and hepatitis B."

"We set out to develop a test that could be simple and inexpensive, but it would provide various parameters on the basis of a single injection with a small volume of blood," said Revzin.

Existing technology currently use a method called flow cytometry, which requires an expensive machine and highly trained specialists. Health workers and AIDS activists in the developing world needed a less expensive device for carrying out tests more easily.

Source: Isaude.net
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Microfluidic test for HIV    HIV    Alexander Revzin    Aydogan Ozcan    University of California - Davis   
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