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publicado em 07/07/2010 às 19h30:00
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High fructose consumption and trans fats lead to severe liver disease

Diet with high levels of these elements not only increases obesity, but also causes significant damage to the liver

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Scientists at Cincinnati Children's Hospital, USA, found that a diet with high levels of fructose, sucrose and trans fats not only increase obesity, but also leads to major diseases of the liver and scar tissue.

"Consumption of fructose is present in 10.2%, on average, diets in the United States and has been linked to many health problems, including obesity, cardiovascular disease and liver disease, such as fatty liver," said lead author study, Rohit Kohli. "We developed a mouse model that is very close to human disease, allowing us to better understand the process involved and the progression of liver disease."

The study also includes preliminary data from a simple blood test to detect the presence of a biological marker that differentiates stages of the disease. Doctors today monitor the progression of liver disease, fatty liver by means of biopsies that are invasive procedures.

Some mice in the study were fed a normal diet of rodents, and others with a diet of 16 weeks of fructose, sucrose and drinking water enriched with solids and even trans fat. His liver was then analyzed for fat content, the formation of scar tissue (fibrosis), and the biological mechanism of harm.

The researchers found that mice fed with the normal pattern of calories lost weight and showed no liver disease. Since rats fed diets high in calories they became obese and developed fatty liver.

"Interestingly, only the group fed the combination of high fructose trans fat and developed advanced liver disease with fibrosis," said Kohli. "This same group also had increased oxidative stress in the liver, increase in inflammatory cells and increased levels of plasma markers of oxidative stress."

Kohli hopes to continue to investigate the mechanism of liver injury caused by too much fructose.

The researchers also plan to use this model to better understand human disease of the liver and perform clinical trials of new therapies and monitoring tools.

"Our data suggest that supplementation with pharmaceutical agents should be tested in our new model to determine whether anyone is able to reverse or protect against scarring and progressive liver damage," he said Kohli.

   Palavras-chave:   Fructose    Trans fat    Liver steatosis    Rohit Kohli    Cincinnati Childrens Hospital   
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