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publicado em 18/05/2010 às 20h00:00
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Lack of protein slows the body's formation of fat cells

Researchers say finding indicates that S6K1 could be targeted for treatment and prevention of obesity

 
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Foto: Divulgação/Univ. de Cincinnati
Sara Kozma, lead researcher at the University of Cincinnati
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Sara Kozma, lead researcher at the University of Cincinnati

Removal of the protein S6K1 slows the formation of new adipocytes (fat cells). Researchers say the finding suggests that S6K1 could be directly targeted for treating or preventing obesity.

The results of this study, led University of Cincinnati (UC) cancer and cell biologist and associate professor Sara Kozma, PhD, are published in the May 18, 2010, edition of Developmental Cell.

In the study, Kozma and her team compared the effects of normal diets versus high-fat diets in mice with and without S6K1. Mice with S6K1 who ate a high-fat diet developed four times more fat cells than mice without S6K1 that were fed the same diet.

Using mouse embryonic stem cells, Kozma and her team were able to demonstrate that the effect of loosing S6K1 was exerted during the first step of fat cell development termed the "commitment stage" and that reintroducing S6K1 into these cells rescued fat cell development. Thus, lack of S6K1 slows fat cell production/renewal.

"We already know that S6K1 plays an important role in longevity, potentially through inhibition of adipose accumulation that has recently been associated with lifespan shortening in humans. These results support such a concept and we are now studying how S6K1 can be targeted to fight obesity," says Kozma. "We need to know more about the timing and means for targeting S6K, to determine whether it could be an effective treatment."

Source: Isaude.net
   Palavras-chave:   Obesity    S6K1 protein    Fat cells    Sara Kozma    University of Cincinnati   
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