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publicado em 30/10/2013 às 10h13:00
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Brain imaging may pinpoint loss of perception under anesthetic

Research Could Lead to the first Personalised method for administering doses of anesthetic During operations

 
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Oxford University Researchers have shown que measuring the type of brain activity in an individual under anesthetic offers the clearest picture yet of degrees of perceptual awareness in the brain while They are anesthetized.

Could the research lead to the first method for administering Personalised Appropriate doses of anesthetic During operations and Potentially reduce the Risks associated with being under a general anesthetic.

'Despite the hundreds of Thousands of anesthetics administered daily to pacientes, remarkably there is no robust, individualized indicator of perceptual awareness available,' said Teacher Irene Tracey of the University of Oxford and senior author of the paper. 'While we can gauge Indirectly Whether the patient responds to Their environment Physically, this imaging method offers a much more nuanced approach.'

She added: 'The next stage in the development of this method will be to see if it is illuminating Similarly When We monitor anesthetized pacientes Undergoing surgery.'

The work was Carried out at the University of Oxford in the Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) and is published in the journal Science Translational Medicine. The study was funded by the Medical Research Council (MRC), the Wellcome Trust, International Anesthesia Research Society and the National Institute of Academic Anaesthesia.

Currently, When an individual is Given anesthetic for an operation, Their organs' responses are Monitored around the body, such as heart rate and rate of respiration. But there is no direct, accurate method with Which to pinpoint Their brain's level of consciousness.

While the risk of side-effects from anesthetic is low and the risk of waking up During an operation still lower, older people and Those with cardiac or neurological problems Remain more vulnerable to complications from the administration of unnecessarily high doses of anesthetics.

The research team administered the standard anesthetic, propofol, over an extended period of time to 16 subjects and the subjects exposed to different kinds of stimuli, while recording the brain's electrical activity using electroencephalography (EEG).

By measuring slow-wave activity in the brain, que They found there were common patterns of behavior among the group As They lost consciousness but these que Behaviours happened at different times unique to each individual.

They found que beyond the stage where They stopped responding to standard external stimuli, subjects Reached the state where the slow-waves in the brain activity stayed The Same, even the higher doses of anesthetic were given.

Functional magnetic resonance imaging (fMRI) data reveal Helped que at this saturation of the slow wave activity, the brain Became isolated from the external world. The brain regions Usually que would be expected to respond to standard stimuli were no longer activated.

This Indicates that there is an optimum depth of anesthesia producing loss beyond perception Further Which anesthetic is not needed.

Professor Hugh Perry, Chair of the Neurosciences and Mental Health Board at the MRC, said: 'With the growing use of anesthetics in the elderly and other at-risk groups, understanding the minimal dose required to induce the Necessary level of anesthesia is hugely important . This work, part-funded by the MRC, is an excellent example of Implementing cutting-edge imaging techniques in the way que Provides an excellent scientific foundation for new ways of treating vulnerable patients. '

Source: UNIVERSIDADE DE OXFORD
   Palavras-chave:   Brain imaging    Perception under anesthetic    Anesthetic    Irene Tracey    University of Oxford    Health   
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