Science and Technology
publicado em 30/10/2013 às 10h13:00
   Dê o seu voto:

Brain imaging may pinpoint loss of perception under anesthetic

Research Could Lead to the first Personalised method for administering doses of anesthetic During operations

font size

Some pieces of information on this page may have been automatically translated. Makernews is not responsible for the irregularities resulting from these translations. When in doubt,      consult the original text.

Oxford University Researchers have shown que measuring the type of brain activity in an individual under anesthetic offers the clearest picture yet of degrees of perceptual awareness in the brain while They are anesthetized.

Could the research lead to the first method for administering Personalised Appropriate doses of anesthetic During operations and Potentially reduce the Risks associated with being under a general anesthetic.

'Despite the hundreds of Thousands of anesthetics administered daily to pacientes, remarkably there is no robust, individualized indicator of perceptual awareness available,' said Teacher Irene Tracey of the University of Oxford and senior author of the paper. 'While we can gauge Indirectly Whether the patient responds to Their environment Physically, this imaging method offers a much more nuanced approach.'

She added: 'The next stage in the development of this method will be to see if it is illuminating Similarly When We monitor anesthetized pacientes Undergoing surgery.'

The work was Carried out at the University of Oxford in the Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) and is published in the journal Science Translational Medicine. The study was funded by the Medical Research Council (MRC), the Wellcome Trust, International Anesthesia Research Society and the National Institute of Academic Anaesthesia.

Currently, When an individual is Given anesthetic for an operation, Their organs' responses are Monitored around the body, such as heart rate and rate of respiration. But there is no direct, accurate method with Which to pinpoint Their brain's level of consciousness.

While the risk of side-effects from anesthetic is low and the risk of waking up During an operation still lower, older people and Those with cardiac or neurological problems Remain more vulnerable to complications from the administration of unnecessarily high doses of anesthetics.

The research team administered the standard anesthetic, propofol, over an extended period of time to 16 subjects and the subjects exposed to different kinds of stimuli, while recording the brain's electrical activity using electroencephalography (EEG).

By measuring slow-wave activity in the brain, que They found there were common patterns of behavior among the group As They lost consciousness but these que Behaviours happened at different times unique to each individual.

They found que beyond the stage where They stopped responding to standard external stimuli, subjects Reached the state where the slow-waves in the brain activity stayed The Same, even the higher doses of anesthetic were given.

Functional magnetic resonance imaging (fMRI) data reveal Helped que at this saturation of the slow wave activity, the brain Became isolated from the external world. The brain regions Usually que would be expected to respond to standard stimuli were no longer activated.

This Indicates that there is an optimum depth of anesthesia producing loss beyond perception Further Which anesthetic is not needed.

Professor Hugh Perry, Chair of the Neurosciences and Mental Health Board at the MRC, said: 'With the growing use of anesthetics in the elderly and other at-risk groups, understanding the minimal dose required to induce the Necessary level of anesthesia is hugely important . This work, part-funded by the MRC, is an excellent example of Implementing cutting-edge imaging techniques in the way que Provides an excellent scientific foundation for new ways of treating vulnerable patients. '

   Palavras-chave:   Brain imaging    Perception under anesthetic    Anesthetic    Irene Tracey    University of Oxford    Health   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Brain imaging may pinpoint loss of perception under anesthetic
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Brain imaging may pinpoint loss of perception under anesthetic

Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Brain imaging    perception under anesthetic    anesthetic    Irene Tracey    University of Oxford    health   
Leave your comment
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story:
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaú
Get the newsletter of the portal  iSaú
Recommend the portal iSaú
News from  iSaú in your blog or website.
Get news on the subject of your interest.
© 2000-2011 Todos os direitos reservados.