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publicado em 08/10/2013 às 12h21:00
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New biomarker for Parkinson's disease may be beneath the skin

Researchers at Harvard Medical School are using skin biopsy to detect the protein alpha-synuclein

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Researchers at Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, found that high levels of a protein called alfa-sinucleína nervous system can be detected on the skin of people with Parkinson's disease (PD).

They suggest that the protein may serve as a biomarker of disease, contributing to identify it before the appearance of symptoms.

According to Roy Freeman, author of the study, the alpha-synuclein occurs throughout the nervous system and although not much is known about its action, has been identified that it is the main component of abnormal clumps of protein bodies (Lewy bodies) that are formed within the cells of the brain of people with Parkinson's disease. There is also evidence that suggests that the protein plays a key role in the development of the disease.

"The alpha-synuclein deposition occurs early in the course of Parkinson's disease, preceding the onset of clinical symptoms," the researchers.

Already there is a view that the symptoms related to the autonomic nervous system, such as changes in temperature, blood pressure regulation and function of intestinal symptoms may precede motor system common in people with Parkinson's.

These autonomic nervous system changes are also reflected in the skin, with signs such as excessive sweating or decreased, changes in skin color and temperature. These symptoms occur in nearly two-thirds of patients with Parkinson's disease, says Professor Freeman.

"The skin may provide a window for access to the nervous system. Based on these clinical observations, we decided to test whether examination of the nerves in the skin biopsy can be used to identify a biomarker Parkinson's" full.

Despite being the most common neurodegenerative disease in the U.S., which affects more than 1 million people, Parkinson's is difficult to diagnose. No standard clinical tests, the disease is often diagnosed only when symptoms such as tremors and stiffness appear, at which many neurons have been destroyed.

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Parkinson's biomarker for Parkinson's    Alpha-synuclein    Harvard Medical School    lewy bodies    Roy Freeman   
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