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publicado em 03/10/2013 às 08h27:00
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Butantan begins to recruit volunteers for vaccine trials against dengue

In the first phase, will be accepted adults 18 to 59 years who have never had dengue. They will receive two doses in six months

 
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Foto: Instituto Butantan
Vaccine is being developed to combat in a single dose, the four types of the disease have been identified in the world
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Vaccine is being developed to combat in a single dose, the four types of the disease have been identified in the world

Began on Wednesday (2) the recruitment of the first 50 volunteers who will receive the Brazilian vaccine against dengue developed by Instituto Butantan.

In the first phase of the project developed with the University of São Paulo (USP) volunteers will be the state capital, and all healthy adults who never had dengue, aged between 18 and 59 years, of both sexes. They will be immunized in two doses with an interval of six months between them.

The vaccine is being developed to combat, in a single dose, four types of disease have been identified worldwide. The technique uses the so-called attenuated. This ignifica the dengue virus itself is modified so that it is able to make people produce antibodies but without developing the disease.

The creation of the vaccine began in 2006, along with the National Institutes of Health in the United States. Viruses were identified in the country, and subsequently transferred to the Butantan in 2010.

Scientists have tested the vaccine in more than 600 Americans and revealed no major side effects, only pain and redness at the injection site, feeling common to vaccines.

However, as the United States is not a region where dengue is endemic, any volunteer who received immunization had contracted the disease before. In Brazil, the tests will also involve people who have had dengue.

Those interested in participating in the study can call the phone (11) 2661-7214 and (11) 2661-3344, or send an email to vacinadengue@usp.br. The next step, which should begin next year, will include people with a history of dengue, and the vaccine will be given in a single dose. 250 volunteers will be the capital city and the city of Ribeirão Preto, in the state.

In the third and final phase will be recruited people from various parts of the country, of various ages. The prediction of the researchers is that the vaccine reaches the population in five years.

Source: AGÊNCIA BRASIL
   Palavras-chave:   Dengue vaccine    Clinical trials    Volunteers    The Butantan Institute    University of sao paulo    Usp   
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