Science and Technology
publicado em 23/08/2013 às 15h00:00
   Dê o seu voto:

Injection genes regenerate cardiac cells to treat diseases

Combination of genes reprogrammed cells of patients with diseases of the heart in the cardiac muscle cell function

 
font size
A-
A+

Some pieces of information on this page may have been automatically translated. Makernews is not responsible for the irregularities resulting from these translations. When in doubt,      consult the original text.



New technique developed by U.S. researchers could help regenerate cardiac cells to treat heart disease.

The team created a new approach that may one day be used to convert cells of patients with heart disease in cardiac muscle cells that could act as a personalized treatment for the condition.

The results were published in the journal Stem Cell Reports.

Researchers have previously reported the ability to convert scar-forming cells in the heart (called fibroblasts) in new functional muscle cells in mice that had suffered heart attacks, thereby regenerating the heart from the inside.

The staff that performed by means of an injection of a combination of three genes in fibroblast cells of animals. "This gene therapy approach resulted in new heart muscle cells that beat in synchrony with neighboring muscle cells and ultimately improve the pumping function of the heart," explains senior author Deepak Srivastava, Gladstone Institute, USA.

In the new research, Srivastava and his colleagues persuaded fibroblasts from human fetal cardiac cells, embryonic stem cells, and skin cells freshly grown in the laboratory to become cells of the heart muscle, using a slightly different combination of genes, which represents an important step towards the use of this technology for regenerative medicine.

The team provides for the introduction of these genes into damaged hearts by gene therapy can further muscle in converted fibroblasts, thus improving heart function. "More than 50% of the cells of the human heart are fibroblasts, providing a wide range of cells that could be harnessed to create new muscle," says Srivastava.

However, further investigation is needed to improve the process of reprogramming adult human cells in this way. Finally, the replacement of the genes for drug molecules which have a similar effect would be a more reliable and more easily accomplished.

Source: Isaude.net
   Palavras-chave:   Cardiac cells    Injection of genes    Heart disease    Deepak Srivastava    Gladstone Institute   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Injection genes regenerate cardiac cells to treat diseases
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Injection genes regenerate cardiac cells to treat diseases


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Cardiac cells    injection of genes    heart disease    Deepak Srivastava    Gladstone Institute   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.