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publicado em 23/08/2013 às 15h00:00
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Injection genes regenerate cardiac cells to treat diseases

Combination of genes reprogrammed cells of patients with diseases of the heart in the cardiac muscle cell function

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New technique developed by U.S. researchers could help regenerate cardiac cells to treat heart disease.

The team created a new approach that may one day be used to convert cells of patients with heart disease in cardiac muscle cells that could act as a personalized treatment for the condition.

The results were published in the journal Stem Cell Reports.

Researchers have previously reported the ability to convert scar-forming cells in the heart (called fibroblasts) in new functional muscle cells in mice that had suffered heart attacks, thereby regenerating the heart from the inside.

The staff that performed by means of an injection of a combination of three genes in fibroblast cells of animals. "This gene therapy approach resulted in new heart muscle cells that beat in synchrony with neighboring muscle cells and ultimately improve the pumping function of the heart," explains senior author Deepak Srivastava, Gladstone Institute, USA.

In the new research, Srivastava and his colleagues persuaded fibroblasts from human fetal cardiac cells, embryonic stem cells, and skin cells freshly grown in the laboratory to become cells of the heart muscle, using a slightly different combination of genes, which represents an important step towards the use of this technology for regenerative medicine.

The team provides for the introduction of these genes into damaged hearts by gene therapy can further muscle in converted fibroblasts, thus improving heart function. "More than 50% of the cells of the human heart are fibroblasts, providing a wide range of cells that could be harnessed to create new muscle," says Srivastava.

However, further investigation is needed to improve the process of reprogramming adult human cells in this way. Finally, the replacement of the genes for drug molecules which have a similar effect would be a more reliable and more easily accomplished.

   Palavras-chave:   Cardiac cells    Injection of genes    Heart disease    Deepak Srivastava    Gladstone Institute   
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