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publicado em 15/08/2013 às 13h00:00
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Cigarette smoke inhibits the activity of genes that protect the heart and lungs

Research indicates that adverse effect is even more pronounced when obese nonsmokers are exposed to secondhand smoke

 
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Cigarette smoke inhibits hundreds of genes that protect the heart and lungs, with an even more pronounced effect when obesity is a factor, new research shows.

New insights into why obese cigarette smokers experience a high risk of heart disease suggest that cigarette smoke affects the activity of hundreds of key genes that both protect the heart and lungs and expose them to damage. The study, published in ACS' Chemical Research in Toxicology, suggests that the effects may be especially profound in obese nonsmokers who inhale "sidesteam smoke" from cigarettes smoldering nearby.

Diana J. Bigelow and colleagues point out that active smoking doubles the risk of heart disease, while second-hand smoke exposure increases this risk by about one-third. They set out to gain more information on why the risks are especially high among people with obesity, using specially fed laboratory mice that are stand-ins for humans in such experiments.

The report describes how mainstream smoke and to a greater extent, sidestream smoke, inhibit the activity of genes that protect the heart and lungs, and activate genes associated with an increased risk of heart disease. Those changes were more profound in obese mice than normal-weight mice. "The present study is the first, to our knowledge, that addresses the in vivo transcriptional response of the heart to cigarette smoke exposure in the setting of high fat diet and obesity, and thus takes a first step toward identifying the molecular basis of adaptive responses that may lead to an increased risk of heart disease in obese smokers," the report states.

Source: Isaude.net
   Palavras-chave:   Cigarette    Cigarette smoke    Smoking    Gene activity    Heart health    Pacific Northwest National Laboratory   
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